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Modes of Action & Resistance Management

Resistance is arithmetic: kill 99% with one site of action and you've just bred the 1%. Here's how to keep chemistry working on your farm.

πŸ“– 7 min readπŸŽ“ Application ScienceπŸ“± Mobile-friendly
Look for the group number on the label β€” HRAC/WSSA for herbicides, FRAC for fungicides, IRAC for insecticides. Same number = same site of action = no resistance benefit from "switching products."

Rotate is good; overlap is better

Old advice was "rotate chemistry each year." Current weed-science consensus: use multiple effective sites of action in the same pass. A weed surviving Group 15 must also survive Group 5 in the tank β€” the odds of both mutations collapse. Rotation across seasons still matters, but the tank mix does the heavy lifting.

"Effective" is the operative word: adding a group your weeds are already resistant to isn't a second site of action, it's expensive water.

The five non-chemical multipliers

Fungicides and insecticides deserve the same discipline

FRAC 11 (strobilurin) resistance in frogeye leaf spot and IRAC 3 (pyrethroid) failures are real in row crops. For fungicides, prefer pre-mixes with two effective FRAC groups and hold single-site products for the pass that needs them. For insects, scout to threshold rather than spraying insurance passes β€” every unnecessary application is selection pressure.

A one-page plan you can actually follow

  1. List your top 3 problem pests/weeds per field.
  2. Write the group numbers you used last season (from records).
  3. Plan this season with β‰₯2 effective groups per target, changing at least one from last year.
  4. Record actual groups applied in your application log β€” that's the data next year's plan needs.

Group classifications per HRAC/WSSA, FRAC, IRAC. Mixing mechanics: adjuvants & tank mixing.

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